2021 USCAP Maude Abbott Lecture - Neuroendocrine Carcinomas na kai da wuya:
A baya, Yanzu da Mai yiwuwa Gaba

BRUCE M. WENIG, MD

Shugaba kuma Babban Memba
Ma'aikatar Pathology
Cibiyar Cancer ta Moffitt
Farfesa na Kimiyyar Oncological
Jami'ar Kudancin Florida
Tampa, Florida

Lokacin gudu: 1 hour 26 Minti

ABUN SHIRIN

Neuroendocrine neoplasms (NEN) yana tasowa a kusan kowace gabo. Ci gaban embryologic na NEN ya kasance batun muhawara ko akwai ko babu asalin ƙwayar jijiyoyi na kowa. Ƙarƙashin jigon asali na asali na jijiyoyi na yau da kullum, wanzuwar hanyar biochemical na yau da kullum a cikin kwayoyin neuroendocrine wanda ya ƙunshi ɗauka da decarboxylation na amine precursors an sanya shi yana ba da damar gano waɗannan kwayoyin halitta ta hanyar tarihi kuma ya haifar da amfani da acronym APUD (Amine Precursor). Uptake da Decarboxylation) don bayyana sel a cikin wannan tsarin. Nazari na gaba ya karyata asalin jijiya na gama gari kuma an karɓi rarrabuwa Tsarin Cell ɗin Neuroendocrine don NEN. Rarraba NEN ya sami juyin halitta wanda tsare-tsare na yanzu ba tare da la'akari da asalin wurin ba sun ba da shawarar yin amfani da nomenclature da aka kafa don gastrointestinal da pancreatic NEN. Baya ga gastrointestinal tract, pancreas da huhu, yanki na kai da wuya yana daga cikin wuraren da ke faruwa ga NEN kuma a cikin wannan yanki na ciwon daji na neuroendocrine shine mafi yawan nau'in shafin yanar gizon NEN. Wannan magana za ta mayar da hankali kan ciwon daji na neuroendocrine na kai da wuyansa suna yin bitar sifofin su na asibiti da kuma tattaunawa game da haɗa su a cikin tsarin rarrabuwa na uniform da aka tsara don wasu takamaiman rukunin yanar gizon NEN.

SABANNAN BAYANAI

1. Tattauna ci gaban embryologic na neuroendocrine neoplasms
2. Bayyana ma'auni na bincike don kai da wuyan neuroendocrine neoplasms wanda ya bambanta waɗannan sharuɗɗa da na wasu shafukan yanar gizo na NEN.
3. Ƙayyade ko tsarin rarraba gama gari na NEN ya shafi kai da wuya NEN